TREND ASSESSMENT: APPLICATIONS FOR HYDROLOGY AND CLIMATE RESEARCH

Trend assessment: applications for hydrology and climate research

The assessment of trends in climatology and hydrology still is a matter of debate.Capturing typical properties of time series, like trends, is highly relevant for the discussion of potential impacts of global warming or flood occurrences.It provides indicators for the separation of anthropogenic signals and natural forcing factors by distinguishing

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Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design.

Antibodies are an important class of therapeutics that have significant clinical impact for the treatment of severe diseases.Computational tools to support antibody drug discovery have been developing at an increasing rate over the last decade and typically rely upon a predetermined co-crystal structure of the SOY ISOFLAVONES antibody bound to the

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Activation of rat transient receptor potential cation channel subfamily V member 1 channels by 2-aminoethoxydiphenyl borate

Background: The transient receptor potential cation channel subfamily V member 1 (TRPV1) channel has been proved to be a molecular integrator of inflammatory pain sensation.2-Aminoethoxydiphenyl borate (2-APB) and its analogs have been noticed as attractive candidates for the development of a selective TRPV1 LAVENDER NEEM BAR SOAP agonist and/or an

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